Reference Library

Discover the ingredients and bacterial strains in our formulations, why we chose them, and the research behind those choices.

Daily Magnificence  10-Day Revival

References

  1. Ravel J et al. Vaginal microbiome of reproductive-age women. PNAS 2011;108(S1):4680–7. https://doi.org/10.1073/pnas.1002611107
  2. Amabebe E, Anumba DOC. The vaginal microenvironment: the physiologic role of lactobacilli. Front Med 2018;5:181. https://doi.org/10.3389/fmed.2018.00181
  3. Gajer P et al. Temporal dynamics of the human vaginal microbiota. Sci Transl Med 2012;4(132):132ra52. https://doi.org/10.1126/scitranslmed.3003605
  4. Amabebe E, Anumba DOC. Female gut and genital tract microbiota-induced crosstalk and differential effects of short-chain fatty acids on immune sequelae. Front Immunol 2020;11:2184. https://doi.org/10.3389/fimmu.2020.02184
  5. Giansanti F et al. Lactoferrin from milk: nutraceutical and pharmacological properties. Pharmaceuticals 2016;9(4):61. https://doi.org/10.3390/ph9040061
  6. Pino A et al. Antimicrobial activity of bovine lactoferrin against Gardnerella species clinical isolates. Front Microbiol 2022;13:1000822. https://doi.org/10.3389/fmicb.2022.1000822
  7. Centers for Disease Control and Prevention. Vulvovaginal candidiasis. Sexually Transmitted Infections Treatment Guidelines, 2021. https://www.cdc.gov/std/treatment-guidelines/candidiasis.htm
  8. Centers for Disease Control and Prevention. Bacterial vaginosis. Sexually Transmitted Infections Treatment Guidelines, 2021. https://www.cdc.gov/std/treatment-guidelines/bv.htm
  9. Rapisarda AMC et al. Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain as a new driver in restoring the normal vaginal microbiota: A randomized, double-blind, placebo-controlled clinical trial. Front Surg 2023;9:1075612. https://doi.org/10.3389/fsurg.2022.1075612
  10. Pino A et al. Oral administration of the probiotic Lacticaseibacillus rhamnosus CA15 in a large cohort of women with bacterial vaginosis and mixed vaginitis: Clinical evidence from a randomized, double-blind, placebo-controlled study. Microorganisms 2025;13(12):2651. https://doi.org/10.3390/microorganisms13122651
  11. Pino A et al. Lacticaseibacillus rhamnosus CA15 (DSM 33960) as a Candidate Probiotic Strain for Human Health. Nutrients 2022;14(22):4902. https://doi.org/10.3390/nu14224902
  12. Parolin C et al. Anti-Candida Activity of Hyaluronic Acid Combined with Lactobacillus crispatus Lyophilised Supernatant: A New Antifungal Strategy. Antibiotics 2021;10(6):628. https://doi.org/10.3390/antibiotics10060628
  13. Commission Regulation (EU) No 432/2012, Annex: nutrient function claims for riboflavin (vitamin B2), vitamins B6, C and D, and zinc. https://www.legislation.gov.uk/eur/2012/432/annex
  14. Pino A et al. Oral intake of the commercial probiotic blend Synbio® for the management of vaginal dysbiosis. J Clin Med 2023;12(1):27. https://doi.org/10.3390/jcm12010027
  15. Silvi S et al. Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines. Int J Food Sci Nutr 2014;65(8):994–1002. https://doi.org/10.3109/09637486.2014.940284
  16. Salvesi C et al. Six-Month Synbio® Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project. Microorganisms 2023;11(3):801. https://doi.org/10.3390/microorganisms11030801
  17. Coman MM et al. Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate. J Med Food 2026;29(7):438–443. First published online 19 November 2025. https://doi.org/10.1177/1096620X251400155
  18. Lepanto MS et al. Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study. Front Immunol 2018;9:2123. https://doi.org/10.3389/fimmu.2018.02123
  19. Oda H et al. Effects of Bovine Lactoferrin on the Maintenance of Respiratory and Systemic Physical Conditions in Healthy Adults—A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2023;15(18):3959. https://doi.org/10.3390/nu15183959
  20. Salvesi C et al. Impact of a probiotic diet on well-being of healthy senior: the PROBIOSENIOR project. J Appl Microbiol 2022;133(5):2941–2953. https://doi.org/10.1111/jam.15747
  21. Depommier C et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine. 2019;25:1096–1103. https://doi.org/10.1038/s41591-019-0495-2
  22. Byndloss MX et al. Microbiota-activated PPAR-γ-signaling inhibits dysbiotic Enterobacteriaceae expansion. Science. 2017;357:570–575. https://doi.org/10.1126/science.aam9949
  23. Furusawa Y et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504:446–450. https://doi.org/10.1038/nature12721
  24. Balendran S, Forsyth C. Non-anaemic iron deficiency. Australian Prescriber. 2021;44:193–196. https://pmc.ncbi.nlm.nih.gov/articles/PMC8671013/
  25. Tawfik YMK et al. Absolute and Functional Iron Deficiency in the US, 2017–2020. JAMA Network Open. 2024;7(9):e2433126. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823909
  26. World Health Organization. WHO Global Anaemia estimates, 2025 edition. Estimates for 2023. https://www.who.int/data/gho/data/themes/topics/anaemia_in_women_and_children
  27. Nappi C et al. Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. Acta Obstet Gynecol Scand 2009;88(9):1031–1035. https://doi.org/10.1080/00016340903117994

Further reading

  • Verdenelli MC et al. Influence of a combination of two potential probiotic strains, L. rhamnosus IMC 501® and L. paracasei IMC 502®, on bowel habits of healthy adults. Lett Appl Microbiol 2011;52(6):596–602. https://doi.org/10.1111/j.1472-765X.2011.03042.x
  • Coman MM et al. SYNBIO® Probiotic and Antioxidant Dietary Supplementation: Clinical Trial Evaluation of Potential Effects on Airline Flight Crew Members' Well-Being. Microorganisms 2023;11(4):924. https://doi.org/10.3390/microorganisms11040924
  • Kim J et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition 2010;26(9):902–909. https://doi.org/10.1016/j.nut.2010.05.011
  • Huda TM et al. Bovine Lactoferrin Compared With Ferrous sulfate for Treating Iron-Deficiency Anemia in Bangladeshi Women—A Randomized Controlled Trial. J Nutr 2026;156(8):101672. https://doi.org/10.1016/j.tjnut.2026.101672
  • Genazzani AD et al. Myo-inositol modulates insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome. J Obstet Gynaecol Res 2014;40(5):1353–1360. https://doi.org/10.1111/jog.12319
  • Berthon BS et al. Oral lactoferrin reduces systemic inflammation, enhances anti-viral responses and modulates immune cell profiles: a randomised controlled trial in healthy, older adults. Br J Nutr 2026;135(9):929–943. https://doi.org/10.1017/S000711452610631X
  • Martarelli D et al. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol 2011;62(6):1689–1696. https://doi.org/10.1007/s00284-011-9915-3
  • El Khoudary SR et al. The Relation Between Systemic Inflammation and the Menopause Transition: The Study of Women's Health Across the Nation. J Clin Endocrinol Metab 2025;110(11):e3566–e3576. https://doi.org/10.1210/clinem/dgaf175
  • Bharadwaj S et al. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. Osteoporos Int 2009;20(9):1603–1611. https://doi.org/10.1007/s00198-009-0839-8
  • Kujirai C et al. Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2026;18(19):3193. https://doi.org/10.3390/nu18193193
  • Kang S et al. Spore-forming Bacillus coagulans SNZ1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: A randomized controlled trial. Food Res Int 2021;146:110428. https://doi.org/10.1016/j.foodres.2021.110428

Research findings relate to the individual strains or ingredients studied, not the final formulations.