Meet our strains.

Not all live bacteria are created equal.

You've probably seen billions of live bacteria advertised on supplement packaging.

But there's something more important than the number.

Which bacteria are they? And what does the science actually say about them?

Different strains can have very different characteristics, even when they belong to the same species.

That's why we look beyond the numbers, choosing identifiable strains with research into the biological environments that matter to us.

From the vaginal microbiome to digestion, immune signalling and the science of healthy ageing.

The strain makes the difference.

Two bacteria can share the same species name and still behave differently.

Take Lacticaseibacillus rhamnosus.

It's a species found in numerous supplements. But the research conducted on one strain cannot automatically be applied to another.

That's where the letters and numbers matter.

LacticaseibacillusGenus
rhamnosusSpecies
CA15Strain

CA15 isn't simply another name for L. rhamnosus. It's a specifically identified strain with its own research history.

And that distinction matters when you're looking for science you can actually trace.

Our strain collection.

Lacticaseibacillus rhamnosus CA15

The ten-day strain.

Studied in two randomised, placebo-controlled human trials involving a total of 260 women with vaginal microbiota imbalance.

Researchers investigated oral CA15 at 10 billion CFU daily for ten days, reporting significant changes in vaginal bacterial communities, pH and clinical measures.

The larger study also followed participants after supplementation ended, finding that improvements in several microbiological measures remained evident at follow-up.

Research focus Vaginal microbiome

Beyond women's intimate health.

The science goes further.

The research into IMC501 and IMC502 doesn't stop at the vaginal microbiome.

Scientists have also investigated this pairing in relation to digestion, nutritional status, inflammatory processes and biological markers associated with ageing.

And some of the findings deserve attention.

  1. 01

    Gut health & digestive function

    In a 12-week placebo-controlled study involving 50 adults, SYNBIO supplementation increased measured levels of lactobacilli and bifidobacteria in stool samples.

    Researchers also recorded improvements in bowel frequency and volume.

    A separate analysis bringing together seven clinical trials and 1,095 participants examined the pairing's relationship with constipation and intestinal regularity.

  2. 02

    Inflammation & healthy ageing

    Ageing is associated with changes in immune function and low-grade chronic inflammation, sometimes described as inflammageing.

    In a six-month clinical research programme involving older adults, SYNBIO was investigated for its effects on gut microbial communities, nutritional status and immune-related markers.

    Researchers observed changes in several inflammatory measures, including TNF-α, alongside other indicators of biological activity.

    The results open an interesting line of enquiry into the relationship between gut bacteria and the biology of ageing.

  3. 03

    Cellular ageing

    What if the microbiome has a role to play in how our cells age?

    Telomeres are protective structures found at the ends of our chromosomes. Their length is one of several biological markers studied in ageing research.

    In an exploratory six-month study involving 46 older adults, researchers reported a difference in telomere shortening between the SYNBIO and comparison groups.

    It is early-stage research, not evidence of longer life.

    But it is a fascinating question: how might our microbial communities interact with the biological processes associated with ageing?

Explore the research.

Science you can trace.

Explore the human trials and laboratory studies behind our strain collection.

Every study is presented with its design, participants, dose, duration and key findings, alongside a link to the original publication.

01 / CA15 · Vaginal microbiomeHuman RCT

200 women. Ten days. A significant shift in vaginal microbiota.

Participants
200 completed
Duration
10 days + 30-day follow-up
Dose
10bn CFU daily
The findings

Women with bacterial vaginosis or mixed vaginitis took oral CA15 or a placebo. At baseline, 97 of 100 women in the CA15 group had BV-range Nugent scores. After ten days, and again at follow-up, none did. No equivalent change was seen with placebo.

Read the peer-reviewed study ↗

Randomised, double-blind, placebo-controlled trial. Pino et al., Microorganisms, 2025.

02 / CA15 · Vaginal microbiomeHuman RCT

The original CA15 clinical trial.

Participants
60 completed
Duration
10 days + 30-day follow-up
Dose
10bn CFU daily
The findings

In women with vaginal dysbiosis, CA15 increased vaginal lactobacilli and reduced several potentially harmful organisms, including Gardnerella, Candida and E. coli. The changes were still evident 30 days after supplementation ended.

Read the peer-reviewed study ↗

Randomised, double-blind, placebo-controlled trial. Rapisarda et al., Frontiers in Surgery, 2023.

03 / SYNBIO · Vaginal microbiomeHuman pilot

Two oral strains. Measurable changes in vaginal bacteria.

Participants
30
Duration
15 days + 7-day follow-up
Dose
5bn CFU daily
The findings

After 15 days of oral SYNBIO, researchers recorded an increase in vaginal lactobacilli and reductions in Gardnerella, Candida and E. coli. At follow-up, the reduction in E. coli remained significant.

Read the peer-reviewed study ↗

Open-label, uncontrolled pilot. Pino et al., Journal of Clinical Medicine, 2023.

04 / SYNBIO · Gut healthHuman RCT

Twelve weeks of research into gut bacteria and regularity.

Participants
50
Duration
12 weeks
Dose
1bn CFU daily, in food
The findings

Healthy adults who consumed the two strains showed increased faecal lactobacilli and bifidobacteria, alongside improvements in stool frequency and volume compared with placebo.

Read the peer-reviewed study ↗

Double-blind, placebo-controlled trial. Verdenelli et al., Letters in Applied Microbiology, 2011.

05 / SYNBIO · Gut healthMeta-analysis

Seven trials. 1,095 participants.

Trials
7
Participants
1,095
Population
Healthy adults
The findings

A systematic review and meta-analysis of randomised trials examined SYNBIO's relationship with constipation and bowel regularity in healthy adults.

Read the peer-reviewed study ↗

Systematic review and meta-analysis. Coman et al., Fermentation, 2024.

06 / SYNBIO · Healthy ageingHuman RCT

Six months. Inflammation and nutrition in older adults.

Duration
6 months
Design
Double-blind RCT
Project
PROBIOSENIOR
The findings

Older adults taking SYNBIO showed reductions in several inflammatory markers, including TNF-α and IL-6, alongside improvements in measures of nutritional status.

Read the peer-reviewed study ↗

Randomised, double-blind, placebo-controlled. Salvesi et al., Microorganisms, 2023.

07 / SYNBIO · Cellular ageingExploratory RCT

A fascinating early finding in cellular-ageing research.

Participants
46
Duration
6 months
Dose
5bn CFU daily
The findings

In a PROBIOSENIOR sub-study, telomeres in white blood cells shortened more slowly in the SYNBIO group than with placebo. It is early, small-scale research, not evidence of longer life.

Read the peer-reviewed study ↗

Randomised, double-blind, placebo-controlled. Coman et al., Journal of Medicinal Food, 2026.

08 / BC5 · Laboratory researchLab study

A vaginal-origin strain, studied in cervical cells.

Model
Human cervical cells
Focus
Chlamydia trachomatis
The findings

Under laboratory conditions, L. crispatus BC5 reduced the ability of Chlamydia trachomatis to infect cervical cells.

Read the peer-reviewed study ↗

Laboratory study. Parolin et al., Frontiers in Microbiology, 2018.

09 / SNZ1969 · Gut healthHuman RCT

Eight weeks. Motility and gut comfort.

Participants
80
Duration
8 weeks
Design
Placebo-controlled
The findings

In adults with mild, intermittent constipation, Bacillus coagulans SNZ1969 was associated with improved intestinal motility and perceived constipation, alongside changes in gut bacterial communities.

Read the peer-reviewed study ↗

Randomised controlled trial. Kang et al., Food Research International, 2021.

Research refers to the individual strains as studied, not to clinical trials of the finished Daughters of Mars formulas.

The details matter.

The species. The strain. The dose. The research.

Because when it comes to live bacteria, the name on the label is only the beginning.

Discover Daily Magnificence →Discover 10-Day Revival →